The disease primarily affects young children but may affect older children and adults. Further investigations may be required if the diagnosis is unclear. Fortysix children with henochschonlein purpura were studied. Jun 20, 2019 henochschonlein purpura hsp is an igamediated, autoimmune hypersensitivity vasculitis of childhood.
Urinalysis is the only investigation required in a classic presentation of hsp. Jan 17, 2015 henoch schonlein purpura refers to an acute or chronic vasculitis affecting primarily small vessels of the skin, joints, g. Clinicoepidemological profile of children with henochschonlein. Henoch schonlein purpura causes skin rash, pain in the abdomen, and joint inflammation. Henoch schonlein purpura usually goes away on its own within a month with no lasting ill effects.
Introduction cassio lynm, ma in jama, february 15, 2012 vol 307, no. A retrospective descriptive study of patients with scholein henoch purpura diagnosis was conducted for 4 years. Henochschonlein purpura hsp is an acute immunoglobulin a igamediated disorder characterized by a generalized vasculitis involving. Henochschonlein purpura american academy of pediatrics. Henochschonlein purpura hsp or iga vasculitis is the most common childhood vasculitis. Background 1st described in 1801 by william heberden, a physician in london, who wrote about a case of a 5 year old boy with hematuria, abdominal pain, joint pains and skin rash. The role of corticosteroid in hemorrhagic bullous henoch schonlein purpura. Henochschonlein purpura diagnosis and treatment mayo clinic. Henochschonlein purpura hsp is the most common form of vasculitis in children. Schonleinhenoch purpura, anaphylactoid purpura rhumatoid purpura diagnosis diagnosis of hsp is established when at least 2 of the following 4 criteria are present. Symptoms can begin in children, most commonly between the ages of 4 and 7 years, soon after an upper respiratory tract infection or a. Rest, plenty of fluids and overthecounter pain relievers may help with symptoms. Hsp results from inflammation of the small blood vessels in the skin and various other tissues within the body. Henochschonlein purpura is a nonthrombocytopenic, purpuric and systemic vasculitis of childhood1 that occurs twice as often in males as in females.
In the presence of certain clinical features the possibility of an underlying vasculitic disease must be considered. It gets its name from two german doctors, johann schonlein and eduard henoch, who. Purpura occur in all cases, joint pains and arthritis in 80%, and abdominal pain in 62%. Henochschonlein purpura hsp is characterised by a nonblanching rash, which commonly affects the lower limbs of children aged 315 years. Henochschonlein purpura is an iga vasculitis characterized by a tetrad of palpable purpura. Question a child recently presented to my office with lower limb petechiae, arthralgia, and abdominal pain characteristic of henochschonlein purpura hsp.
The rash was sometimes purpuric, at other times composed of red macules tike those of an exanthem. Schonlein henoch purpura is the most common infantile vasculitis and is mostly clinically diagnosed. This was followed in 3 days by an asymptomatic purpuric. Henoch schonlein purpura hsp is a disease involving inflammation of small blood vessels. This smallvessel vasculitis is mediated by immunoglobulin a igacontaining immune complexes and is characterized by nonthrombocytopenic purpura, abdominal pain, arthralgias, and renal disease. Henochschonlein purpura hsp is a disease involving inflammation of small blood vessels.
Health professionals diagnosis henoch schonlein purpura through blood tests elevated iga. Henoch schonlein purpura hsp is an immunemediated vasculitis. Hsp can affect blood vessels in the bowel and the kidneys, as well. Jul 26, 2017 henochschonlein purpura hsp is a disease that causes small blood vessels to become inflamed and leak blood. Henochschonlein purpura hsp is a rare disease that causes the blood vessels in your skin to become irritated and swollen. Henoch schonlein purpura also known as anaphylactoid purpura is a type of vasculitis that affects small blood vessels and characterized by elevated immunoglobulin a iga. Diatesis hemorragica, reaccion a farmacos, sepsis, malos tratos. Henochschonlein purpura hsp is a common leukocytoclastic vasculitis seen in children. Early recognition and treatment of henochschonlein purpura in. Henoch schonlein purpura causes a purple spotted skin rash which lasts around one to four weeks, and is often marked by relapses. Symptoms of this disease include skin lesions, joint pain, blood in urine hematuria, and abdominal pain. Henochschonlein purpura hsp, also known as iga vasculitis, is a disease of the skin, mucous membranes, and sometimes other organs that most commonly. Dec 10, 2018 henoch schonlein purpura hsp, also called immunoglobulin a vasculitis igav, is a vascular disease that primarily affects small blood vessels. Purpura, arthritis, and abdominal pain are known as the classic triad of henochschonlein purpura.
Roberts pf1, waller ta, brinker tm, riffe iz, sayre jw, bratton rl. The treatment of henoch schonlein purpura is directed toward the most significant area of involvement. Henochschonlein purpura allergy and clinical immunology. When the blood vessels bleed, you get a rash called purpura. Iga vasculitis henoch schonlein purpura as the first. An acute respiratory infection precedes purpura in a high proportion of affected young children. The prognosis for patients with henoch schonlein purpura is generally excellent. Apr 05, 2020 a 35yearold white man with no prior illness presented with a 10day history of colicky abdominal pain worsened with meals, and back pain. Clinical course of extrarenal symptoms in henoch schonlein purpura. Nov 25, 2015 background henochschonlein purpura hsp or anaphylactoid purpura. Their clinical manifestations included palpable purpura in 100%, subcutaneous edema in 30%, arthritisarthralgia in 78%, gastrointestinal involvement in 56% and renal abnormalities in 30%. Henochschonlein purpura hsp is a form of leukocytoclastic or smallvessel vasculitis, most often observed in children. Among the 12 patients with recurrent or chronic henochschonlein purpura, three had arthritis, four exhibited signs and symptoms of abdominal involvement and seven of kidney disease. This guideline has been adapted for statewide use with the support of the victorian paediatric clinical network.
The main clinical features are skin purpura, arthritis, abdominal pain, gastrointestinal bleeding, and nephritis. Henoch schonlein purpura was confirmed by finding iga deposition on vessels within gastric and duodenal mucosa, while immunohistochemistry also identified dense focal t cell infiltration in. Thus both schonlein and henoch were aware that purpura. The inflammation causes blood vessels in the skin, intestines. Henoch schonlein purpura presenting as hemorrhagic vesicles and bullae. Henochschonlein purpura hsp is vasculitis of the small vessels, the most common vasculitis of the childhood and is uncommon in adults. The source of information was medical records and a data gathering guide containing the studied variables was used. Severe hemorrhagic bullous lesions in henoch schonlein purpura. Most children and many adults with acute leukaemia can expect to be cured, while chronic leukaemia can be successfully managed. Some include gastrointestinal hemorrhage as a fourth criterion. Precedidas por una infecciondel tracto respiratorio superiorpatologia mediada por elsistema inmuneinducida por factoresambientales.
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